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LENS EPITHELIAL PROTEIN; LENEP

LENS EPITHELIAL PROTEIN; LENEP

Alternative titles; symbolsLEP503, RAT, HOMOLOG OF; LEP503HGNC Approved Gene Symbol: LENEPCytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:154,99...

Alternative titles; symbols

  • LEP503, RAT, HOMOLOG OF; LEP503

HGNC Approved Gene Symbol: LENEP

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:154,993,585-154,994,320 (from NCBI)

▼ Cloning and Expression
Wen et al. (2001) obtained a full-length cDNA encoding LENEP, which they called LEP503, by 5-prime and 3-prime RACE of human lens epithelium RNA. The deduced 61-amino acid protein shares 77% identity with rat Lep503. Northern blot analysis revealed a 600-bp transcript expressed in lens epithelial cells, but not in other cell lines tested.

▼ Gene Structure
Wen et al. (2001) determined that the 5-prime flanking sequence of the LENEP gene lacks a consensus TATA box, but contains a CCAAT box and a series of 11 GATA consensus sequences. There are 3 SP1 (189906) sites, 2 AP1 (165160) sites, a STAT-binding site, and a GC box element. An SP1 site and an AP1 site are conserved between the human and rodent LENEP genes. By deletion and mutation analysis of the promoter region contained in a reporter plasmid, Wen et al. (2001) identified 1 AP1 site and 1 SP1 site that were critical for the expression of LENEP in lens epithelial cells.

▼ Mapping
By FISH, Wen et al. (2001) mapped the LENEP gene to chromosome 1q22.

Tags: 1q21.3