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MEAN PLATELET VOLUME/COUNT QUANTITATIVE TRAIT LOCUS 6; MPVCQTL6

MEAN PLATELET VOLUME/COUNT QUANTITATIVE TRAIT LOCUS 6; MPVCQTL6

Cytogenetic location: 7q22.3 Genomic coordinates (GRCh38): 7:104,900,000-107,800,000▼ MappingGieger et al. (2011) performed metaanalyses of genomewide associ...

Cytogenetic location: 7q22.3 Genomic coordinates (GRCh38): 7:104,900,000-107,800,000

▼ Mapping
Gieger et al. (2011) performed metaanalyses of genomewide association studies (GWAS) for MPV and PLT. Their analyses included 18,600 (13 studies, MPV) and 48,666 (23 studies, PLT) individuals of European descent, respectively, and up to approximately 2.5 million genotyped or imputed single-nucleotide polymorphisms (SNPs). Gieger et al. (2011) identified 2 SNPs in the 7q22.3 region, rs342293 and rs342275, that are 3 nucleotides away from each other at the FLJ36031-PIK3CG locus (601232) as significantly associated with MPV, with a p value of 7.03 x 10(-57), and PLT, with a p value of 5.57 x 10(-25).

Tags: 7q22.3