Alternative titles; symbolsVOLTAGE-GATED POTASSIUM CHANNEL 9.3; KV9.3HGNC Approved Gene Symbol: KCNS3Cytogenetic location: 2p24.2 Genomic coordinates (GRCh38...
Alternative titles; symbols
HGNC Approved Gene Symbol: KCNS3
Cytogenetic location: 2p24.2 Genomic coordinates (GRCh38): 2:17,877,846-17,932,960 (from NCBI)
For general information on voltage-gated potassium channels, see KCNS1 (602905).
▼ Cloning and Expression
Stocker and Kerschensteiner (1998) cloned a full-length rat cDNA encoding the potassium channel alpha subunit Kcns3, which they named Kv9.3. The predicted Kcns3 protein has all of the hallmarks of a voltage-gated potassium channel. Northern blot analysis detected Kcns3 expression in a wide variety of tissues, with the most abundant expression found in lung and brain.
▼ Gene Function
Stocker and Kerschensteiner (1998) did not detect inward or outward currents in Xenopus oocytes that had been injected with rat Kcns3 cRNA. They noted that alpha subunits belonging to the Kv9 subfamily appear to modulate the electrophysiologic properties of other voltage-gated potassium channels.
The human KCNS3 coding sequence has been deposited in GenBank (AF043472). The KCNS3 gene has been tentatively mapped to 2p24.
▼ Molecular Genetics
Hao et al. (2005) analyzed 3 SNPs in the KCNS3 gene in 228 individuals with extreme airway hyperresponsiveness (see 600807) and 444 controls. In single-SNP analysis, the rs1031771 G allele (OR, 1.42; p = 0.006) and the rs1031772 T allele (OR, 1.40; p = 0.018) were associated with a significantly higher risk of airway hyperresponsiveness; haplotype analysis also detected a significant association (p = 0.006). Hao et al. (2005) suggested that SNPs located in the 3-prime downstream region of KCNS3 have a significant role in the etiology of airway hyperresponsiveness.