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LOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 10; LRP10

LOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 10; LRP10

Alternative titles; symbolsLRP9HGNC Approved Gene Symbol: LRP10Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:22,871,612-22,881,712 (from NCB...

Alternative titles; symbols

  • LRP9

HGNC Approved Gene Symbol: LRP10

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:22,871,612-22,881,712 (from NCBI)

▼ Cloning and Expression
Sugiyama et al. (2000) cloned mouse Lrp10, which they called Lrp9. Following cleavage of a 17-amino acid signal sequence, the mature type I membrane protein contains 696 amino acids and has a calculated molecular mass of 74.8 kD. It contains 2 N-terminal CUB domains separated by a single ligand-binding repeat, followed by a cluster of 3 additional ligand-binding repeats, a central transmembrane domain, and a proline-rich C-terminal intracellular region. Northern blot analysis detected abundant Lrp10 expression in mouse liver, kidney, lung, and heart, with weaker expression in spleen and brain. Northern blot analysis of human tissues revealed a slightly different expression pattern, with a 3-kb transcript present in blood leukocytes, lung, placenta, small intestine, liver, kidney, spleen, thymus, colon, skeletal muscle, and heart, but not in brain.

▼ Gene Function
Sugiyama et al. (2000) found that transfection of Chinese hamster ovary cells with mouse Lrp10 increased cholesteryl ester formation in the presence of apolipoprotein E (APOE; 107741)-enriched beta-very low density lipoproteins. They concluded that LRP10 may play a role in the uptake of APOE-containing lipoproteins.

▼ Mapping
By radiation hybrid analysis, Sugiyama et al. (2000) mapped the human LRP10 gene to chromosome 14q11.2. They mapped the mouse Lrp10 gene to a region of chromosome 14 that shares homology of synteny with human chromosome 14q11.

Tags: 14q11.2