HGNC Approved Gene Symbol: MRPL47Cytogenetic location: 3q26.33 Genomic coordinates (GRCh38): 3:179,588,284-179,604,645 (from NCBI)▼ DescriptionMitochondria h...
HGNC Approved Gene Symbol: MRPL47
Cytogenetic location: 3q26.33 Genomic coordinates (GRCh38): 3:179,588,284-179,604,645 (from NCBI)
Mitochondria have their own translation system for production of 13 inner membrane proteins essential for oxidative phosphorylation. MRPL47 is a component of the large subunit of the mitochondrial ribosome that is encoded by the nuclear genome (Koc et al., 2001).
▼ Cloning and Expression
By searching databases using bovine Mrpl47 as query, Koc et al. (2001) identified human MRPL47. They also identified MRPL47 homologs in mouse, Drosophila, C. elegans, and yeast, but not in E. coli or Arabidopsis. Mouse and human MRPL47 share 85.7% amino acid identity.
Gross (2017) mapped the MRPL47 gene to chromosome 3q26.33 based on an alignment of the MRPL47 sequence (GenBank BC021575) with the genomic sequence (GRCh38) .