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ELONGATOR ACETYLTRANSFERASE COMPLEX, SUBUNIT 6; ELP6

ELONGATOR ACETYLTRANSFERASE COMPLEX, SUBUNIT 6; ELP6

Alternative titles; symbolsTRANSMEMBRANE PROTEIN 103; TMEM103CHROMOSOME 3 OPEN READING FRAME 75; C3ORF75HGNC Approved Gene Symbol: ELP6Cytogenetic location: 3p21...

Alternative titles; symbols

  • TRANSMEMBRANE PROTEIN 103; TMEM103
  • CHROMOSOME 3 OPEN READING FRAME 75; C3ORF75

HGNC Approved Gene Symbol: ELP6

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:47,495,639-47,513,724 (from NCBI)

▼ Description
ELP6 is 1 of 6 subunits of the elongator complex. Elongator promotes RNA polymerase II transcript elongation through histone acetylation in the nucleus and also regulates translational fidelity through tRNA modification in the cytoplasm (summary by Close et al., 2012).

▼ Cloning and Expression
By mass spectrometric analysis of proteins that copurified with the elongator complex in HEK293 cells, Close et al. (2012) identified ELP6. SDS-PAGE detected ELP6 at an apparent molecular mass of 30 kD.

▼ Gene Function
Using RNA interference, Close et al. (2012) found that depletion of any of the elongator complex components Elp1 (IKBKAP; 603722), Elp3 (612722), Elp5 (615019), or Elp6 in B16-F10 mouse melanoma cells reduced cell motility in a wound-healing assay and reduced the capacity of cells to form colonies in soft agar.

▼ Mapping
Hartz (2013) mapped the ELP6 gene to chromosome 3p21.31 based on an alignment of the ELP6 sequence (GenBank AK000218) with the genomic sequence (GRCh37).

Tags: 3p21.31