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PLACENTA-SPECIFIC GENE 9; PLAC9

PLACENTA-SPECIFIC GENE 9; PLAC9

HGNC Approved Gene Symbol: PLAC9Cytogenetic location: 10q22.3 Genomic coordinates (GRCh38): 10:80,131,660-80,145,358 (from NCBI)▼ Cloning and ExpressionBy mi...

HGNC Approved Gene Symbol: PLAC9

Cytogenetic location: 10q22.3 Genomic coordinates (GRCh38): 10:80,131,660-80,145,358 (from NCBI)

▼ Cloning and Expression
By microarray assay to search for mouse genes enriched in placenta, Galaviz-Hernandez et al. (2003) identified Plac9 as a placenta-enriched gene expressed in mouse 16-cell morula cDNA. By database analysis, they identified human PLAC9, which encodes a deduced 97-amino acid protein. The deduced 108-amino acid mouse protein has a predicted signal peptide, a coiled-coil domain, and shares 73% identity with human PLAC9. Northern blot analysis of mouse placenta and embryo RNA at 12.5 and 18.5 days postcoitum (dpc) detected predominant expression in placenta.

▼ Gene Structure
Galaviz-Hernandez et al. (2003) determined that the mouse Plac9 gene contains 4 exons, with exons 4a and 4b defining different Plac9 isoforms.

▼ Mapping
By database analysis, Galaviz-Hernandez et al. (2003) mapped the PLAC9 gene to chromosome 10q22.3 and the mouse Plac9 gene to chromosome 15.

Tags: 10q22.3