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NUCLEAR FACTOR RELATED TO KAPPA-B BINDING PROTEIN; NFRKB

NUCLEAR FACTOR RELATED TO KAPPA-B BINDING PROTEIN; NFRKB

HGNC Approved Gene Symbol: NFRKBCytogenetic location: 11q24.3 Genomic coordinates (GRCh38): 11:129,863,635-129,895,595 (from NCBI)▼ Cloning and ExpressionNuc...

HGNC Approved Gene Symbol: NFRKB

Cytogenetic location: 11q24.3 Genomic coordinates (GRCh38): 11:129,863,635-129,895,595 (from NCBI)

▼ Cloning and Expression
Nuclear factor-kappa-B (NFKB1, 164011; NFKB2, 164012) binds in vitro to several of the kappa-B regulatory elements found in cellular and viral genes. Another DNA binding protein, R-kappa-B, binds to a related variant of the kappa-B site that regulates interleukin-2 receptor alpha-chain (IL2RA; 147730) gene expression, a critical event in T-cell activation (Adams et al., 1992).

▼ Mapping
By Southern blot analysis of a human-mouse somatic cell hybrid panel and in situ hybridization using a fluorescent genomic probe, Adams et al. (1992) mapped the NFRKB gene to 11q24-q25. It was the most telomeric marker identified up to that point on 11q.

Tags: 11q24.3