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SEMINAL PLASMA PROTEIN, BOVINE, HOMOLOG OF, 1; BSPH1

SEMINAL PLASMA PROTEIN, BOVINE, HOMOLOG OF, 1; BSPH1

Alternative titles; symbolsBSP, BOVINE, HOMOLOG OF, 1BINDER OF SPERM PROTEIN, BOVINE, HOMOLOG OF, 1BOVINE SEMINAL PLASMA PROTEIN-LIKE 1HGNC Approved Gene Symbol:...

Alternative titles; symbols

  • BSP, BOVINE, HOMOLOG OF, 1
  • BINDER OF SPERM PROTEIN, BOVINE, HOMOLOG OF, 1
  • BOVINE SEMINAL PLASMA PROTEIN-LIKE 1

HGNC Approved Gene Symbol: BSPH1

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:47,967,257-47,992,169 (from NCBI)

▼ Cloning and Expression
By searching a human genomic database for sequences similar to the fibronectin (135600) type II (Fn2) domains of bovine Bsp, followed by RT-PCR of epididymal RNA and by 5-prime and 3-prime RACE, Lefebvre et al. (2007) identified full-length BSPH1. The deduced 133-amino acid protein contains an N-terminal signal sequence and 2 Fn2 domains separated by a 7-amino acid linker. The 2 Fn2 domains contain 8 cysteines that may form intramolecular disulfide bridges. A single free cysteine predicted to become the N-terminal residue following removal of the signal peptide may participate in intermolecular disulfide bridges. The deduced mature BPSH1 protein has 115 amino acids and a molecular mass of 13.8 kD. RT-PCR detected strong BSPH1 expression in epididymis and weak expression in testis, but no expression in prostate, seminal vesicles, brain, intestine, or lung. Database analysis revealed 3 Bsp homologs in mouse, only 2 of which appeared to be expressed, and a single Bsp homolog in chimpanzee and monkey. Bovine Bsp and its homologs share a high degree of conservation, particularly surrounding the cysteine residues.

▼ Gene Structure
Lefebvre et al. (2007) determined that the BSPH1 gene contains 6 exons and spans 26 kb. The introns are rich in Alu repeat elements.

▼ Mapping
By genomic sequence analysis, Lefebvre et al. (2007) mapped the BSPH1 gene to chromosome 19. They mapped the 3 mouse Bsp orthologs to chromosome 7.

Tags: 19q13.33