Alternative titles; symbolsPROTEASOME COMPONENT 9; PSC9HC9HGNC Approved Gene Symbol: PSMA4Cytogenetic location: 15q25.1 Genomic coordinates (GRCh38): 15:78,5...
Alternative titles; symbols
HGNC Approved Gene Symbol: PSMA4
Cytogenetic location: 15q25.1 Genomic coordinates (GRCh38): 15:78,540,404-78,552,416 (from NCBI)
Proteasomes are multicatalytic proteinase complexes consisting of a set of nonidentical polypeptide components, such as PSMA4 (Tamura et al., 1991).
▼ Cloning and Expression
By biochemical analysis and screening a liver cell line cDNA library with rat Psma4, Tamura et al. (1991) isolated a cDNA encoding human PSMA4, which they called HC9. The predicted 261-amino acid protein has a calculated molecular mass of 29.5 kD. HC9 is highly homologous to HC2 (PSMA1; 602854), HC3 (PSMA2; 176842), and HC8 (PSMA3; 176843), particularly in the N-terminal half, and is 99% identical to the rat protein.
The International Radiation Hybrid Mapping Consortium mapped the PSMA4 gene to chromosome 15 (WI-9202).
Amos et al. (2008) placed the CHRNA3 (118503), CHRNA5 (118505), CHRNB4 (118509), and PSMA4 genes within a 100-kb region on chromosome 15q25.1.