Alternative titles; symbolsRTE1▼ TEXTNishimoto et al. (2001) mapped a repressor of telomerase expression to a 2.7-cM region on 10p15.1 by microcell-mediated chro...
Alternative titles; symbols
Nishimoto et al. (2001) mapped a repressor of telomerase expression to a 2.7-cM region on 10p15.1 by microcell-mediated chromosome transfer (MMCT) into a telomerase-positive cell line. Since loss of chromosome 10 is frequent in malignant gliomas (see 137800), as demonstrated by loss of heterozygosity (LOH), Leuraud et al. (2003) investigated the specific relationship between telomerase reactivation and the frequently demonstrated LOH on 10p15.1 in high-grade gliomas. In a series of 51 high-grade gliomas analyzed for LOH on chromosome 10 and for telomerase activity, a statistically significant relationship of telomerase activity to LOH of 10p was found, suggesting that a telomerase repressor gene located on 10p15.1 is inactivated in high-grade gliomas.