HGNC Approved Gene Symbol: TSPAN3Cytogenetic location: 15q24.3 Genomic coordinates (GRCh38): 15:77,041,403-77,071,108 (from NCBI)▼ DescriptionTSPAN3 belongs ...
HGNC Approved Gene Symbol: TSPAN3
Cytogenetic location: 15q24.3 Genomic coordinates (GRCh38): 15:77,041,403-77,071,108 (from NCBI)
TSPAN3 belongs to the large family of tetraspanins, so named because they contain 4 transmembrane domains. Tetraspanins are frequently expressed at the cell surface in association with each other and with other molecules, such as integrins (see ITGB1; 135630), and they function to regulate cell adhesion, migration, proliferation, and differentiation (summary by Todd et al., 1998).
▼ Cloning and Expression
By searching an EST database for sequences containing a tetraspanin consensus sequence, Todd et al. (1998) identified human TSPAN3. The deduced 253-amino acid protein contains 4 transmembrane domains and other features characteristic of tetraspanins, including conservation of charged residues in or near the transmembrane domains, similar to ion channels, and of 4 cysteines in the second extracellular domain. Northern blot and EST database analyses revealed robust and widespread TSPAN3 expression. Todd et al. (1998) also identified mouse Tspan3, which shares over 90% amino acid identity with human TSPAN3.
Hartz (2009) mapped the TSPAN3 gene to chromosome 15q24.3 based on an alignment of the TSPAN3 sequence (GenBank AF054840) with the genomic sequence.