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LATE CORNIFIED ENVELOPE PROTEIN 1B; LCE1B

LATE CORNIFIED ENVELOPE PROTEIN 1B; LCE1B

Alternative titles; symbolsLATE ENVELOPE PROTEIN 2; LEP2HGNC Approved Gene Symbol: LCE1BCytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:152,811,...

Alternative titles; symbols

  • LATE ENVELOPE PROTEIN 2; LEP2

HGNC Approved Gene Symbol: LCE1B

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:152,811,970-152,813,107 (from NCBI)

▼ TEXT
For background information on the LCE gene cluster, see 612603.

▼ Cloning and Expression
By database analysis to identify human orthologs of mouse genes encoding late envelope proteins (LEPs), Marshall et al. (2001) identified LCE1B, which they called LEP2. RT-PCR detected LEP2 in human skin, but not in heart or esophagus.

Using real-time PCR, Jackson et al. (2005) detected low LCE1B expression in human fetal, arm, penal, and abdominal skin. Little to no expression was detected in vulva, tongue, and esophagus.

▼ Gene Structure
Jackson et al. (2005) determined that LCE1B is a single-exon gene.

▼ Mapping
By genomic sequence analysis, Marshall et al. (2001) mapped the LCE1B gene within the LCE gene cluster on chromosome 1q21. Jackson et al. (2005) stated that the mouse Lce1b gene maps to a syntenic LCE gene cluster on chromosome 3F1.

Tags: 1q21.3