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UBIQUITIN-LIKE 7; UBL7

UBIQUITIN-LIKE 7; UBL7

HGNC Approved Gene Symbol: UBL7Cytogenetic location: 15q24.1 Genomic coordinates (GRCh38): 15:74,445,976-74,461,187 (from NCBI)▼ Cloning and ExpressionFrom l...

HGNC Approved Gene Symbol: UBL7

Cytogenetic location: 15q24.1 Genomic coordinates (GRCh38): 15:74,445,976-74,461,187 (from NCBI)

▼ Cloning and Expression
From large-scale screening of a bone marrow stromal cell (BMSC) cDNA library, Liu et al. (2003) identified UBL7, a novel cDNA encoding a deduced 380-amino acid protein with a predicted molecular mass of 40.6 kD. The protein, which they designated BMSC-UbP, contains a UBQ domain at its N terminus and a ubiquitin-associated domain at its C terminus. It shares moderate homology with several ubiquitin-like proteins including UBQLN1 (605046) and UBQLN2 (300264). Northern blot analysis revealed an approximately 1.3-kb UBL7 transcript in all human tissues tested. RT-PCR detected expression of UBL7 in several tumor cell lines.

▼ Gene Function
Liu et al. (2003) found that expression of UBL7 was significantly down-regulated in PMA-stimulated BMSC but was not obviously changed in LPS-stimulated BMSC. UBL7 expression was up-regulated in LPS-stimulated acute promyelocytic HL60 cells but remained unchanged in PMA-stimulated HL60 cells. Liu et al. (2003) suggested that UBL7 may play a role in the regulation of BMSC function or cell differentiation through an evocator- and cell-specific pattern.

▼ Mapping
By sequence analysis, Liu et al. (2003) mapped the UCL7 gene to chromosome 15q22.3-q23.

Tags: 15q24.1