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PROTEIN ARGININE METHYLTRANSFERASE 2; PRMT2

PROTEIN ARGININE METHYLTRANSFERASE 2; PRMT2

Alternative titles; symbolsHETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN METHYLTRANSFERASE 1-LIKE 1; HRMT1L1HMT1-LIKE 1HGNC Approved Gene Symbol: PRMT2Cytogenetic loca...

Alternative titles; symbols

  • HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN METHYLTRANSFERASE 1-LIKE 1; HRMT1L1
  • HMT1-LIKE 1

HGNC Approved Gene Symbol: PRMT2

Cytogenetic location: 21q22.3 Genomic coordinates (GRCh38): 21:46,635,155-46,665,684 (from NCBI)

▼ Cloning and Expression
Katsanis et al. (1997) isolated HRMT1L1, a novel transcript from chromosome 21 similar to the rat protein arginine N-methyltransferase-1 gene (PRMT1; 602950) reported by Lin et al. (1996). Katsanis et al. (1997) found that HRMT1L1 was expressed in all tissues they investigated.

Scott et al. (1998) further characterized HRMT1L1 and HRMT1L2. By Northern blot analysis, they found that HRMT1L1 is expressed as a 2.4-kb transcript in various adult and fetal tissues.

In his review, Wolf (2009) reported that 2 splice variants of PRMT2 encode an identical 433-amino acid protein with an N-terminal SRC (190090) homology-3 (SH3) domain and a predicted central catalytic domain.

▼ Gene Function
Katsanis et al. (1997) noted that the function of protein methyltransferases is posttranslational methylation of arginine residues. Two types of activity had been described, attributed to different classes of enzymes. One methylates myelin protein zero (MPZ; 159440); the other was originally thought to methylate histones, but was later found to methylate hnRNPs far more efficiently. The authors suggested that HRMT1L1, a human homolog of yeast RMT1, associates with hnRNPs.

Scott et al. (1998) found that HRMT1L1 could not methylate HNRNPA1 (164017) or any other tested substrate in vitro, and did not complement a yeast arginine methyltransferase mutant strain.

▼ Gene Structure
Wolf (2009) reported that exon 3 of the PRMT2 gene contains the translational start site.

▼ Mapping
Katsanis et al. (1997) mapped the PRMT2 gene to chromosome 21 by study of monochromosomal cell hybrids and fine mapped the gene by PCR analysis of a partial chromosome 21 hybrid panel to a telomeric position on 21q22.3. Hybridization to a YAC that was positive for S100B (176990) indicated that PRMT2 is no more than 10 kb from S100B. S100B was the most telomeric chromosome 21 gene known at that time.

Tags: 21q22.3