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LIPOCALIN 10; LCN10

LIPOCALIN 10; LCN10

HGNC Approved Gene Symbol: LCN10Cytogenetic location: 9q34.3 Genomic coordinates (GRCh38): 9:136,738,169-136,742,939 (from NCBI)▼ DescriptionMembers of the l...

HGNC Approved Gene Symbol: LCN10

Cytogenetic location: 9q34.3 Genomic coordinates (GRCh38): 9:136,738,169-136,742,939 (from NCBI)

▼ Description

Members of the lipocalin family, such as LCN10, have a common structure consisting of an 8-stranded antiparallel beta-barrel that forms a cup-shaped ligand-binding pocket or calyx. Lipocalins generally bind small hydrophobic ligands and transport them to specific cells (Suzuki et al., 2004).

▼ Cloning and Expression

Suzuki et al. (2004) cloned mouse Lcn10, which encodes a deduced 182-amino acid protein. They identified human LCN10 by database analysis. Northern blot analysis detected Lcn10 expression in mouse epididymis only, and epididymal expression began at 3 weeks of age. In situ hybridization detected Lcn10 in the epithelium lining the initial segment and segment 2 of mouse epididymis.

▼ Gene Function

Suzuki et al. (2004) found that expression of Lcn10 in mouse epididymis disappeared after castration and was only partially restored by testosterone administration.

▼ Mapping

By genomic sequence analysis, Suzuki et al. (2004) mapped the LCN10 gene to an LCN gene cluster on chromosome 9q34. They mapped the mouse Lcn10 gene to a syntenic region of mouse chromosome 2A3.

Tags: 9q34.3