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ENHANCER OF POLYCOMB HOMOLOG 2; EPC2

ENHANCER OF POLYCOMB HOMOLOG 2; EPC2

Alternative titles; symbolsENHANCER OF POLYCOMB, DROSOPHILA, HOMOLOG OF, 2EPC-LIKEHGNC Approved Gene Symbol: EPC2Cytogenetic location: 2q23.1 Genomic coordin...

Alternative titles; symbols

  • ENHANCER OF POLYCOMB, DROSOPHILA, HOMOLOG OF, 2
  • EPC-LIKE

HGNC Approved Gene Symbol: EPC2

Cytogenetic location: 2q23.1 Genomic coordinates (GRCh38): 2:148,644,750-148,788,490 (from NCBI)

▼ Cloning and Expression

The NuA4 histone acetyltransferase (HAT) complex is responsible for acetylation of the N-terminal tails of histone H4 (see 602822) and H2A (see 613499) in yeast. Its catalytic subunit, Esa1, is homologous to human TIP60 (HTATIP; 601409). Using affinity purification, Western blot analysis, cell fractionation, immunoprecipitation, and mass spectrometry, Doyon et al. (2004) found that TIP60 and its splice variant, TIP60B/PLIP, were part of a multisubunit NuA4 complex with HAT activity in several human cell lines. They identified human homologs for 11 of the 12 yeast NuA4 subunits, including EPC2. The EPC2 protein contains 763 amino acids.

▼ Mapping

The International Radiation Hybrid Mapping Consortium mapped the EPC2 gene to chromosome 2 (RH65535).

▼ Animal Model

In a study of 1,751 knockout alleles created by the International Mouse Phenotyping Consortium (IMPC), Dickinson et al. (2016) found that knockout of the mouse homolog of human EPC2 is homozygous-lethal (defined as absence of homozygous mice after screening of at least 28 pups before weaning).

Tags: 2q23.1