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MILIA, MULTIPLE ERUPTIVE; MEM

MILIA, MULTIPLE ERUPTIVE; MEM

Multiple eruptive milia (MEM) is a rare condition in which clusters of milia (benign keratinous cysts) develop suddenly on the face and upper trunk (summary by L...

Multiple eruptive milia (MEM) is a rare condition in which clusters of milia (benign keratinous cysts) develop suddenly on the face and upper trunk (summary by Langley et al., 1997).

▼ Clinical Features

Thies and Schwarz (1961) described a 66-year-old patient with acute eruption of milia on the face, neck, shoulders, and upper chest. Heard et al. (1971) described a seemingly identical situation in a man who had onset of the abnormality in childhood and whose father had the same condition. (The father died at age 72 of carcinoma of the colon.) The case of Thies and Schwarz (1961) was not familial.

Langley et al. (1997) described a 71-year-old man with a 1-month history of an asymptomatic eruption of white papules on the upper trunk and extremities. The lesions began on the shoulders and spread quickly to involve the arms, chest, and back. Individual papules measured between 1 and 3 mm in diameter. Biopsy specimens showed several small cysts lined by stratified squamous epithelium with keratin arranged in concentric laminated layers. Sebaceous ducts were observed in the walls of the cysts, focally, indicating that they were of follicular infundibular rather than acrosyringeal.

▼ Inheritance

Father-to-son transmission of multiple eruptive milia in the family described by Heard et al. (1971) suggested autosomal dominant inheritance.

Langley et al. (1997) noted that Schimpf and Pons (1974) had reported a mother and son with multiple eruptive milia on the face and upper trunk.

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