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E2F1 mRNA STABILIZING LONG NONCODING RNA; EMSLR

E2F1 mRNA STABILIZING LONG NONCODING RNA; EMSLR

Alternative titles; symbolsE2F1 mRNA STABILIZING FACTOR; EMSHGNC Approved Gene Symbol: EMSLRCytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:101,...

Alternative titles; symbols

  • E2F1 mRNA STABILIZING FACTOR; EMS

HGNC Approved Gene Symbol: EMSLR

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:101,308,306-101,311,338 (from NCBI)

▼ Description
EMSLR is an oncogenic long noncoding RNA (lncRNA) that regulates the function of c-Myc (190080) by modulating E2F1 (189971) mRNA stability (Wang et al., 2019).

▼ Cloning and Expression
Using RACE experiments and fractionation analysis, Wang et al. (2019) showed that EMSLR, which they called EMS, contains 1,098 nucleotides. RNA-fluorescence in situ hybridization analysis in A549 cells localized EMS predominantly in the cytoplasm.

▼ Gene Function
By RNA sequencing analysis, Wang et al. (2019) identified EMS as a c-Myc responsive lncRNA. Knockdown and ectopic expression analyses showed that EMS functioned as an oncogenic lncRNA and promoted cell proliferation by accelerating G1/S cell cycle progression. EMS expression was transcriptionally regulated by c-Myc. EMS exerted its oncogenic function and regulated tumor cell growth by stabilizing E2F1 mRNA. The stabilizing effect of EMS on E2F1 was found to be dependent on RALY (614663). Additional experiments indicated that EMS connects c-Myc to cell cycle control and tumorigenesis by modulating E2F1 mRNA stability.

▼ Gene Structure
Wang et al. (2019) stated that the EMS gene contains 2 exons.

▼ Mapping
Wang et al. (2019) stated that the EMS gene maps to chromosome 7.

Tags: 7q22.1