Alternative titles; symbolsK23KA23HGNC Approved Gene Symbol: KRT23Cytogenetic location: 17q21.2 Genomic coordinates (GRCh38): 17:40,922,695-40,937,645 (from ...
Alternative titles; symbols
HGNC Approved Gene Symbol: KRT23
Cytogenetic location: 17q21.2 Genomic coordinates (GRCh38): 17:40,922,695-40,937,645 (from NCBI)
Keratin-23 is a member of the type I keratin family (Zhang et al., 2001).
▼ Cloning and Expression
Sodium butyrate (NaBu) induces differentiation and apoptosis in human pancreatic cancer cell lines. By a suppression subtractive hybridization-based technique, Zhang et al. (2001) identified a novel intermediate filament protein, designated KRT23, that is highly induced upon NaBu treatment of pancreatic cancer cells. The KRT23 cDNA expresses a 1.65-kb mRNA encoding a deduced 422-amino acid protein that shares 42 to 46% sequence identity with other type I keratins within the alpha-helical rod domain. Trichostatin A, a potent and specific inhibitor of histone deacetylase, similarly induced KRT23 mRNA expression. Treatment with either actinomycin D or cycloheximide efficiently blocked the induction of KRT23 mRNA by either sodium butyrate or trichostatin A. The results suggested that KRT23 is a novel member of the acidic keratin family that is induced in pancreatic cancer cells undergoing differentiation by a mechanism involving histone hyperacetylation. The authors also showed that expression of cyclin-dependent kinase inhibitor p21 (CDKN1A; 116899) is necessary for efficient induction of KRT23 mRNA bu histone deacetylase inhibitors.