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SECRETOGLOBIN, FAMILY 1D, MEMBER 2; SCGB1D2

SECRETOGLOBIN, FAMILY 1D, MEMBER 2; SCGB1D2

Alternative titles; symbolsLIPOPHILIN B; LPNBHGNC Approved Gene Symbol: SCGB1D2Cytogenetic location: 11q12.3 Genomic coordinates (GRCh38): 11:62,242,238-62,2...

Alternative titles; symbols

  • LIPOPHILIN B; LPNB

HGNC Approved Gene Symbol: SCGB1D2

Cytogenetic location: 11q12.3 Genomic coordinates (GRCh38): 11:62,242,238-62,244,811 (from NCBI)

▼ Description
Members of the secretoglobin family, such as SCGB1D2, are secreted proteins of about 10 kD that are found in high concentrations in fluids of lung, lacrimal gland, salivary gland, prostate, uterus, and other tissues. Secretoglobins form stable dimers prior to secretion (summary by Jackson et al., 2011).

▼ Cloning and Expression
Zhao et al. (1999) cloned SCGB1D12, which they called lipophilin B, from a human uterus cDNA library. The deduced 90-amino acid prelipophilin B protein has a calculated molecular mass of 9.9 kD. Removal of the N-terminal signal sequence yields a mature 69-amino acid protein with a predicted molecular mass of 7.8 kD. RT-PCR detected lipophilin B expression in thymus, prostate, testis, salivary gland, skeletal muscle, kidney,trachea, uterus, mammary gland, and ovary. Little to no expression was present in small intestine, spleen, placenta, bone marrow, leucocytes, and lacrimal gland.

▼ Mapping
Using FISH, Zhao et al. (1999) mapped the SCGB1D2 gene to chromosome 10q23. However, Gross (2013) mapped the SCGB1D2 gene to chromosome 11q12.3 based on an alignment of the SCGB1D2 sequence reported by Zhao et al. (1999) (GenBank AJ224172) with the genomic sequence (GRCh37).

Tags: 11q12.3