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ZINC FINGER PROTEIN 683; ZNF683

ZINC FINGER PROTEIN 683; ZNF683

Alternative titles; symbolsHOMOLOG OF BLIMP1 IN T CELLS; HOBITHGNC Approved Gene Symbol: ZNF683Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:...

Alternative titles; symbols

  • HOMOLOG OF BLIMP1 IN T CELLS; HOBIT

HGNC Approved Gene Symbol: ZNF683

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:26,361,631-26,374,535 (from NCBI)

▼ Cloning and Expression
In a study of transcripts of human cytomegalovirus (HCMV) CD8+ T cells, Hertoghs et al. (2010) found that ZNF683 showed specific expression in latent HCMV-specific T cells and in total effector-type cells. They stated that the ZNF683 protein is a close homolog of BLIMP1 (PRDM1; 603423), sharing 78.1% sequence identity in the zinc finger region. Braun et al. (2015) stated that ZNF683, which they called HOBIT, arose from genomic duplication of the BLIMP1 gene.

▼ Gene Function
Vieira Braga et al. (2015) showed that human HOBIT is expressed in effector-type CD8+ T cells but not in naive T cells. HOBIT displayed transcriptional activity at BLIMP1 target sites. HOBIT was both necessary and sufficient for the production of IFN-gamma (IFNG; 147570). Vieira Braga et al. (2015) proposed that HOBIT is a transcriptional regulator in long-lived quiescent effector T cells and allows the cells to respond to periodic recurrent infections. This permits the immune system to rapidly respond to latent viruses such as CMV without the normal T-cell differentiation process.

Mackay et al. (2016) demonstrated that Hobit is specifically unregulated in tissue-resident memory T cells, and together with related Blimp1 mediates the development of these cells in skin, gut, liver, and kidney in mice. The Hobit-Blimp1 transcriptional module is also required for other populations of tissue-resident lymphocytes, including natural killer T cells and liver-resident NK cells, all of which share a common transcriptional program. Hobit and Blimp1 are the central regulators of this universal program that instructs tissue retention in diverse tissue-resident lymphocyte populations.

▼ Mapping
Gross (2016) mapped the ZNF683 gene to chromosome 1p36.11 based on an alignment of the ZNF683 sequence (GenBank BC028731) with the genomic sequence (GRCh38).

Tags: 1p36.11