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ZINC FINGER PROTEIN 74; ZNF74

ZINC FINGER PROTEIN 74; ZNF74

HGNC Approved Gene Symbol: ZNF74Cytogenetic location: 22q11.21 Genomic coordinates (GRCh38): 22:20,394,150-20,408,454 (from NCBI)▼ Cloning and ExpressionAubr...

HGNC Approved Gene Symbol: ZNF74

Cytogenetic location: 22q11.21 Genomic coordinates (GRCh38): 22:20,394,150-20,408,454 (from NCBI)

▼ Cloning and Expression
Aubry et al. (1993) found that the ZNF74 gene was hemizygously deleted in 23 out of 24 DiGeorge syndrome (188400) patients tested. ZNF74 mRNA transcripts were detected in human and mouse embryos but not in adult tissues. Sequence analysis of a corresponding cDNA demonstrated an open reading frame encoding 12 zinc finger motifs of the Kruppel/TFIIIA type, as well as N-terminal and C-terminal non-zinc finger domains. Changes in dosage of this putative transcription factor occurring with deletion of ZNF74 may be involved in DiGeorge developmental anomalies.

▼ Mapping
Aubry et al. (1992) mapped the ZNF74 gene to chromosome 22q11.2 by hybridization to a panel of somatic cell hybrids containing various deletions of chromosome 22.

Tags: 22q11.21