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PROTEIN-TYROSINE PHOSPHATASE, RECEPTOR-TYPE, F POLYPEPTIDE-INTERACTING PROTEIN ALPHA 4; PPFIA4

PROTEIN-TYROSINE PHOSPHATASE, RECEPTOR-TYPE, F POLYPEPTIDE-INTERACTING PROTEIN ALPHA 4; PPFIA4

Alternative titles; symbolsPTPRF-INTERACTING PROTEIN ALPHA-4LIPRIN-ALPHA-4HGNC Approved Gene Symbol: PPFIA4Cytogenetic location: 1q32.1 Genomic coordinates (...

Alternative titles; symbols

  • PTPRF-INTERACTING PROTEIN ALPHA-4
  • LIPRIN-ALPHA-4

HGNC Approved Gene Symbol: PPFIA4

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:203,026,490-203,078,735 (from NCBI)

▼ Description
PPFIA4, or liprin-alpha-4, belongs to the liprin-alpha gene family. See liprin-alpha-1 (LIP1, or PPFIA1; 611054) for background on liprins.

▼ Cloning and Expression
Serra-Pages et al. (1998) identified a family of genes encoding LIP1-related proteins, or liprins. The sequence of the predicted partial 500-amino acid liprin-alpha-4 protein is 75% identical to that of LIP1. Northern blot analysis revealed that the liprin-alpha-4 gene is expressed as a 7.5-kb mRNA only in heart, brain, and skeletal muscle.

Tags: 1q32.1