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MICRO RNA 193A; MIR193A

MICRO RNA 193A; MIR193A

Alternative titles; symbolsmiRNA193AHGNC Approved Gene Symbol: MIR193ACytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:31,559,995-31,560,082 (f...

Alternative titles; symbols

  • miRNA193A

HGNC Approved Gene Symbol: MIR193A

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:31,559,995-31,560,082 (from NCBI)

▼ Cloning and Expression
Sun et al. (2011) reported the mature mouse Mir193a sequence as AACUGGCCUACAAAGUCCCAGU.

▼ Gene Function
Sun et al. (2011) stated that mouse Mir193a and Mir193b (614734) share the same seed sequence. When introduced during induction of brown fat differentiation, antagomirs targeting Mir193a, Mir193b, or Mir365 (MIR365A; 614735) reduced lipid accumulation and expression of adipogenic markers in stromal vascular cells cultured from mouse interscapular brown fat and brown preadipocytes. However, knockdown of these miRNAs after differentiation had little effect. Expression of Mir193a, Mir193b, or Mir365 inhibited differentiation of mouse C2C12 myoblasts into multinucleated myotubes.

▼ Mapping
Hartz (2012) mapped the MIR193A gene to chromosome 17q11.2 based on an alignment of the mature MIR193A sequence (AACUGGCCUACAAAGUCCCAGU) with the genomic sequence (GRCh37).

Sun et al. (2011) reported that the mouse Mir193a gene maps to chromosome 11, about 14 kb from the Mir365-2 (MIR365B) gene.

Tags: 17q11.2