Cytogenetic location: 3q28 Genomic coordinates (GRCh38): 3:188,200,000-192,600,000▼ MappingHu et al. (2011) performed a genomewide association scan of 5,408 ...
Cytogenetic location: 3q28 Genomic coordinates (GRCh38): 3:188,200,000-192,600,000
Hu et al. (2011) performed a genomewide association scan of 5,408 subjects (2,331 individuals with lung cancer and 3,077 controls) followed by a 2-stage validation among 12,722 subjects (6,313 cases and 6,409 controls). The combined analyses identified 6 well-replicated single-nucleotide polymorphisms (SNPs) with independent effects and significant lung cancer associations. One was rs4488809, located in the first intron of TP63 (603273) on chromosome 3q28 (p = 7.2 x 10(-26)). Miki et al. (2010) had identified rs4488809 in a Japanese genomewide association study of lung adenocarcinoma. Hu et al. (2011) confirmed the locus at 5p15.33 in the TERT-CLPTM1L region (LNCR3; 612571) characterized by rs465498 and rs2736100 (p = 1.2 x 10(-20) and p = 1.0 x 10(-27), respectively).