tRNA VALINE (ANTICODON AAC) 1-4; TRV-AAC1-4

Alternative titles; symbols

• tRNA-VAL (ANTICODON AAC) 1-4
• TRANSFER RNA VALINE (AAC) 1-4
• TRANSFER RNA VALINE 1; TRNAV1
• tRNA VALINE 1; TRV1

HGNC Approved Gene Symbol: TRV-AAC1-4

Cytogenetic location: 5q35.3 Genomic coordinates (GRCh38): 5:181,218,269-181,218,341 (from NCBI)

▼ Description
There appear to be about 1,300 tRNA genes in the human genome (Hatlen and Attardi, 1971). Arnold et al. (1986) detected a minimum of 13 valine tRNA genes in genomic blots of human DNA.

▼ Cloning and Expression
Craig et al. (1989) identified a human genomic DNA clone containing a cluster of 3 tRNA genes: 2 valine tRNA genes with anticodons of AAC (TRNAV1) and CAC (TRNAV2), encoding the major and minor cytoplasmic valine tRNA isoacceptors, respectively, and a lysine tRNA(CUU) gene. The cluster studied by Craig et al. (1989) contained at least 9 Alu elements, 3 of which were located between the valine tRNA(AAC) and lysine tRNA genes.

▼ Mapping
Gross (2014) mapped the TRV-AAC1-4 gene to chromosome 5q35.3 based on an alignment of the sequence containing TRV-AAC1-4 and 2 other tRNA genes reported by Craig et al. (1989) (GenBank M33940) with the genomic sequence (GRCh37).