HGNC Approved Gene Symbol: ASB12Cytogenetic location: Xq11.2 Genomic coordinates (GRCh38): X:64,224,193-64,230,606 (from NCBI)▼ DescriptionProteins of the AS...
HGNC Approved Gene Symbol: ASB12
Cytogenetic location: Xq11.2 Genomic coordinates (GRCh38): X:64,224,193-64,230,606 (from NCBI)
Proteins of the ASB family, such as ASB12, contain central tandem ankyrin (see 612641) repeats and a C-terminal suppressor of cytokine signaling (SOCS) box. SOCS box proteins are predicted to be involved in protein degradation by acting as a bridge between substrate proteins and E3 ubiquitin protein ligases (see 601623) (review by Kile et al., 2002).
▼ Gene Function
Kohroki et al. (2005) found that epitope-tagged ASB12 and several other ASB family members interacted with endogenous CUL5 (601741) and RBX2 (RNF7; 603863) in immunoprecipitated HEK293 cells. The ASB proteins did not interact with CUL2 (603135) or RBX1 (603814).
Hartz (2013) mapped the ASB12 gene to chromosome Xq11.2 based on an alignment of the ASB12 sequence (GenBank AF403030) with the genomic sequence (GRCh37).