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ANKYRIN REPEAT- AND SOCS BOX-CONTAINING PROTEIN 12; ASB12

ANKYRIN REPEAT- AND SOCS BOX-CONTAINING PROTEIN 12; ASB12

HGNC Approved Gene Symbol: ASB12Cytogenetic location: Xq11.2 Genomic coordinates (GRCh38): X:64,224,193-64,230,606 (from NCBI)▼ DescriptionProteins of the AS...

HGNC Approved Gene Symbol: ASB12

Cytogenetic location: Xq11.2 Genomic coordinates (GRCh38): X:64,224,193-64,230,606 (from NCBI)

▼ Description
Proteins of the ASB family, such as ASB12, contain central tandem ankyrin (see 612641) repeats and a C-terminal suppressor of cytokine signaling (SOCS) box. SOCS box proteins are predicted to be involved in protein degradation by acting as a bridge between substrate proteins and E3 ubiquitin protein ligases (see 601623) (review by Kile et al., 2002).

▼ Gene Function
Kohroki et al. (2005) found that epitope-tagged ASB12 and several other ASB family members interacted with endogenous CUL5 (601741) and RBX2 (RNF7; 603863) in immunoprecipitated HEK293 cells. The ASB proteins did not interact with CUL2 (603135) or RBX1 (603814).

▼ Mapping
Hartz (2013) mapped the ASB12 gene to chromosome Xq11.2 based on an alignment of the ASB12 sequence (GenBank AF403030) with the genomic sequence (GRCh37).

Tags: Xq11.2