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ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 34B; ANKRD34B

ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 34B; ANKRD34B

Alternative titles; symbolsDENDRITIC CELL PROGENITOR PROTEIN, 58-KD; DP58DENDRITIC CELL PHOSPHOPROTEIN, 58-KDHGNC Approved Gene Symbol: ANKRD34BCytogenetic locat...

Alternative titles; symbols

  • DENDRITIC CELL PROGENITOR PROTEIN, 58-KD; DP58
  • DENDRITIC CELL PHOSPHOPROTEIN, 58-KD

HGNC Approved Gene Symbol: ANKRD34B

Cytogenetic location: 5q14.1 Genomic coordinates (GRCh38): 5:80,556,754-80,570,291 (from NCBI)

▼ Description

ANKRD34B is a cytosolic phosphoprotein induced during differentiation of bone marrow (BM) cells into progenitor dendritic cells (DCs) (Al-Shaibi and Ghosh, 2004).

▼ Cloning and Expression

Al-Shaibi and Ghosh (2004) identified Ankrd34b, which they called Dp58, as a cytosolic 58-kD protein in mouse BM cells. Dp58 was present only in differentiating BM cells and was absent from DCs. The deduced Dp58 protein contains 508 amino acids. Western blot analysis confirmed that mouse Dp58 is a phosphoprotein.

▼ Mapping

Gross (2019) mapped the ANKRD34B gene to chromosome 5q14.1 based on an alignment of the ANKRD34B sequence (GenBank BC137441) with the genomic sequence (GRCh38).

Tags: 5q14.1